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NAICS 541714: Research and Development in Biotechnology (except Nanobiotechnology)

NAICS 541714

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms. This sector supports federal initiatives in precision medicine, infectious disease mitigation, biosecurity, and advanced bioprocessing, often involving recombinant DNA technology, protein engineering, cell line development, and high-throughput screening.

Industry Spending Overview

Federal obligations, top contractors and agencies, and related industry codes for NAICS 541714.

AI Industry Description

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms...

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms. This sector supports federal initiatives in precision medicine, infectious disease mitigation, biosecurity, and advanced bioprocessing, often involving recombinant DNA technology, protein engineering, cell line development, and high-throughput screening. In the government contracting landscape, this NAICS code serves as a critical conduit for translating academic and private-sector biotech innovations into mission-critical public health and defense capabilities, frequently intersecting with biomedical engineering, regulatory science, and clinical trial design. Top contractors in this space include Deloitte Consulting LLP, CFD Research Corporation, and PM Consulting Group LLC, reflecting a mix of large professional services firms and specialized small businesses with deep expertise in biostatistics, bioinformatics, and translational research. These firms often serve as technical integrators, bridging laboratory discoveries with scalable, compliant, and government-ready solutions, particularly in areas requiring FDA-aligned development pathways or defense-relevant biosurveillance capabilities. The Department of Health and Human Services and the Department of Defense are the primary awarding agencies, with HHS funding biomedical innovation through NIH and BARDA programs, while DoD supports biodefense, battlefield medical readiness, and countering biological threats through agencies like DARPA and the U.S. Army Medical Research and Development Command. Demand is driven by pandemic preparedness, medical countermeasure development, and next-generation biothreat detection systems. The competitive landscape is highly technical and innovation-driven, with opportunities concentrated in contract research organizations, specialized R&D services, and government-sponsored translational partnerships. Contractors with proven experience in GMP compliance, biosafety level containment, and federal regulatory submission processes are best positioned to compete in this high-stakes, mission-critical sector.

Small business size standard

The SBA threshold that decides who can bid NAICS 541714 work as a small business.

SBA threshold
1,000 employees
Applies to the whole industry code

The SBA cap for this NAICS (13 CFR 121.201). A business at or under it can self-certify as small for work in this code, which is what makes it eligible for a small-business set-aside. The cap is set per NAICS, so the same company can be small in one code and not in another.

13 CFR 121.201, effective January 1, 2026. The SBA revises the table roughly once a year.

Key metrics

Federal obligations and activity under NAICS 541714, last 12 months.

Total Obligations

$979.5M

Last 12 months

Average Award Size

$2.3M

Per awarded contract

Opportunities Posted

1,729

Last 12 months

Active Contracts

178

Currently open

Awarded Contracts

420

Last 12 months

Awards Expiring

531

End date within 12 months

Contractors Awarded

284

Last 12 months

YoY Growth

+6.3%

vs. prior 12 months

Top contractors

Companies with the highest total award value under NAICS 541714, ranked by dollars won.

Ranked by Total Awards
ALBERT B. SABIN VACCINE INSTITUTE, INC. (THE)$263.6M
SHIONOGI INC$156.1M
Please_see_Spreadsheet$120.8M
KALEO, INC.$96.1M
VERICEL CORPORATION$34.9M
PERSONALIS, INC.$18.3M
STI LEGACY, INC.$11.6M
SNA INTERNATIONAL LLC$11.6M
CHENEGA RELIABLE SERVICES LLC$11.3M
OXOS MEDICAL INC$9.6M
Top 10 combined$733.8M14

Top agencies

Federal agencies directing the most contract spending toward NAICS 541714.

Ranked by Total Awards
Department Of Health And Human Services$795.7M
Department Of Defense$74.3M
Department Of Health And Human Services (hhs)$34.1M
Department Of Veterans Affairs$31.6M
National Aeronautics And Space Administration$15.6M
Department Of Defense (dod)$12.2M
Department Of The Interior$9.6M
Department Of Homeland Security$2.8M
Department Of Agriculture$2.7M
Department Of The Interior (doi)$510K
Top 10 combined$979.0M416

Competition

How many companies historically bid on federal awards in NAICS 541714, from bidder counts reported on USAspending.

Usually Single-Bid

Half or more of reported awards drew exactly one bidder, usually a sign of incumbent-held work rather than an open field. · 4,646 reported awards

Median Bidders

1

Per reported award, all-time

Single-Bid Awards

65%

Share of reported awards with one bidder

10+ Bidder Awards

14%

Share of reported awards with 10+ bidders

Reported Awards

4,646

87% of 5,353 total awards

Bidder Count Distribution by Fiscal Year

Share of reported awards in each bidder-count bracket per federal fiscal year.

How this code compares up the NAICS hierarchy. Parent cohorts pool every code under their prefix, so they are the steadier baseline when a 6-digit sample is thin.

Industry FamilyCompetitionMedian BiddersSingle-BidBidder MixReported Awards
541714This Code
Research and Development in Biotechnology (except Nanobiotechnology)
Usually Single-Bid165%
4,64687% of 5,353
54171NAICS Industry
Fewer Bidders242%
247,51682% of 300,775
5417Industry Group
Scientific Research and Development Services
Fewer Bidders240%
283,90283% of 340,442
541Subsector
Fewer Bidders249%
2,933,64485% of 3,439,240
54Sector
Professional, Scientific, and Technical Services
Fewer Bidders249%
2,933,64485% of 3,439,240

Bidder counts reported on past federal awards in this NAICS (USAspending). An open opportunity has no bidders yet, so this is the historical norm for similar work, not a fact about this solicitation. Not all awards report bidder counts, and fewer bidders often means incumbent-held work rather than an easier win. Federal reporting of bidder counts fell from ~96% of awards (FY2016) to ~30% (FY2018 onward); the chart shows shares of reported awards, and washed-out stretches mark years with fewer than 30 of them.

Related NAICS codes

Industries similar to Research and Development in Biotechnology (except Nanobiotechnology), by shared sector, subsector, and industry group.

Research and Development in Nanotechnology

This U.S. industry comprises establishments primarily engaged in conducting nanotechnology research ...
541713Same industry groupHigh similarity

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

This U.S. industry comprises establishments primarily engaged in conducting research and experimenta...
541715Same industry groupHigh similarity

Research and Development in the Social Sciences and Humanities

This industry comprises establishments primarily engaged in conducting research and analyses in cogn...
541720Same industry groupHigh similarity

Offices of Lawyers

This industry comprises offices of legal practitioners known as lawyers or attorneys (i.e., counselo...
541110Same subsectorMedium similarity

Offices of Notaries

This industry comprises establishments (except offices of lawyers and attorneys) primarily engaged i...
541120Same subsectorMedium similarity

title Abstract and Settlement Offices

This U.S. industry comprises establishments (except offices of lawyers and attorneys) primarily enga...
541191Same subsectorMedium similarity

All Other Legal Services

This U.S. industry comprises establishments of legal practitioners (except offices of lawyers and at...
541199Same subsectorMedium similarity

Offices of Certified Public Accountants

This U.S. industry comprises establishments of accountants that are certified to audit the accountin...
541211Same subsectorMedium similarity

Explore contracts across multiple NAICS codes Browse all NAICS Codes

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NAICS 541714 FAQ

Frequently Asked Questions

NAICS code 541714 covers Research and Development in Biotechnology (except Nanobiotechnology). This U.S. industry comprises establishments primarily engaged in conducting biotechnology (except nanobiotechnology) research and experimental development. Biotechnology (except nanobiotechnology) research and experimental development involves the study of the use of microorganisms and cellular and biomolecular processes to develop or alter living or non-living materials. This research and development in biotechnology (except nanobiotechnology) may result in development of new biotechnology (except nanobiotechnology) processes or in prototypes of new or genetically-altered products that may be reproduced, utilized, or implemented by various industries. Illustrative Examples: Cloning research and experimental development laboratories DNA technologies (e.g., microarrays) research and experimental development laboratories Nucleic acid chemistry research and experimental development laboratories Protein engineering research and experimental development laboratories Recombinant DNA research and experimental development laboratories Cross-References. Establishments primarily engaged in--

Recently Posted in Research and Development in Biotechnology (except Nanobiotechnology)

NAICS: 541714
New
SBIR / STTR
USDA SBIR/STTR Topic 8.2 — Plant Production and Protection - Biology
Solicitation # USDA-NIFA-TOPIC-8.2
The USDA National Institute of Food and Agriculture is soliciting proposals under Topic 8.2 for Plant Production and Protection - Biology. This initiative focuses on advancing crop production and protection through the development of innovative plant breeding methods, diagnostic technologies for diseases, and the creation of new food and non-food crop plants. Research efforts are directed toward improving plant characteristics to mitigate biotic and abiotic stresses, developing new genotypes for commercial applications, and creating tools to support the health of natural and domesticated pollinators. This opportunity is a total small business set-aside under the SBIR/STTR mandate, restricting eligibility to companies with fewer than 500 employees. Managed by the United States Department of Agriculture, the program is led by Dr. Christopher Philips. Interested parties can find further details and application guidelines through the NIFA website.
National Institute of Food and Agriculture

POSTED

1 day ago

DEADLINE

N/A
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NAICS: 541714
New
Federal
BWA Identification Core & Assay DevelopmentThe BWA Identification Core and Assay Development subcontract, managed under the Department of Defense agency W6QK Acc-Apg, focuses on the creation and supply of core biological detection technology and assays for U.S. Navy EMBD IDS projects. The primary objective is to develop assays capable of identifying toxins, viruses, and bacteria with sensitivity and specificity levels that match laboratory PCR standards. To ensure accuracy, the project utilizes biological agent panels and simulants during the testing phase. The scope of work requires the delivery of a biological detection engine, specialized assay kits, and comprehensive performance data. This effort is categorized under NAICS code 541714 and is slated for performance in Gunpowder. The solicitation was posted on November 6, 2026, with a response deadline set for December 7, 2026.
W6QK Acc-Apg

POSTED

3 days ago

DEADLINE

in 28 days
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NAICS: 541714
New
Federal
Firefox
Solicitation # DARPA-PS-26-137
The Firefox program, managed by the DARPA Biological Technologies Office, is a 36-month, three-phase initiative seeking to develop a 100-channel, non-invasive brain-computer interface with 50-micron spatial and 100-microsecond temporal resolution. The program focuses on two primary technical hurdles: the creation of components for dynamic rastering and scanning of coherent optical signals to target multiple regions of interest, and the development of non-digital data processing architectures capable of handling high data rates and computational burdens. Multiple awards are anticipated, with funding ranging between 4 million and 7 million dollars per award. Awards will be issued as Other Transaction for Prototype agreements under 10 U.S.C. 4022, utilizing a milestone-based payment schedule. The selection process is multi-staged, beginning with an abstract evaluation based on technical comprehension, technical ability, and budget realism, followed by an Oral Presentation Proposal for selected candidates. Proposers must be registered in the System for Award Management and possess a Unique Entity Identifier. Key compliance requirements include adherence to ANSI laser safety limits for human tissue exposure, Cybersecurity Maturity Model Certification, and strict guidelines regarding organizational conflicts of interest and foreign influence risk assessments.
Defense Advanced Research Projects Agcy

POSTED

3 days ago

DEADLINE

in 21 days
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NAICS: 541714
New
Federal
Future Program: Laguna
Solicitation # DARPA-SN-27-15
Special Notice DARPA-SN-27-15, issued by the Defense Advanced Research Projects Agency Biological Technologies Office, serves as a public notification for the forthcoming Laguna program. This notice is intended for information and program planning purposes and does not constitute a formal solicitation for proposals. The program is anticipated to be a 36-month effort focused on the development and demonstration of defense-relevant specialty products formulated from U.S.-produced raw materials. These products must meet or exceed the critical performance requirements of existing military materials. Key deliverables for the program include predictive tools for material properties, life cycle assessments, technoeconomic analyses, and commercialization strategy plans. The primary point of contact for the initiative is Dr. William Mounfield. While this notice provides an overview of research interests, DARPA will not accept submissions at this time. Formal solicitation details and submission instructions will be posted on sam.gov upon release. All communications regarding this notice must remain unclassified.
Defense Advanced Research Projects Agcy

POSTED

4 days ago

DEADLINE

in 21 days
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NAICS: 541714
New
Grant
Cooperative Agreement for affiliated Partner with Rocky Mountain Cooperative Ecosystem Studies Unit
Solicitation # G27AS00062
The U.S. Geological Survey is seeking a partner within the Rocky Mountain Cooperative Ecosystem Studies Unit to establish a cooperative agreement for research aimed at improving Chronic Wasting Disease surveillance. The project focuses on developing a robust, automated, and reproducible analytical pipeline to standardize Real-Time Quaking Induced Conversion assay data analysis, reducing the reliance on subjective interpretation. Key deliverables include the creation of machine-learning models using LSTM, CNN-LSTM, or hybrid architectures to classify fluorescence curves, the development of an open-source application via R-Shiny or Streamlit/Python for data ingestion and visualization, cross-laboratory validation across at least three independent facilities, and a peer-reviewed publication. The total program funding is estimated at 145,220 dollars for a single award, with an anticipated period of performance from April 1, 2027, to March 31, 2032. Applications must be submitted through grants.gov by December 8, 2026, and are evaluated based on purpose and relevance, technical approach, qualifications and past performance, and budget clarity. Recipients must comply with Department of the Interior general terms, geospatial data standards under the Geospatial Data Act of 2018, and federal regulations regarding financial reporting and conflict of interest. Required submission documents include a Project Abstract Summary, Biographical Sketches, and Current and Pending Support forms for all senior key personnel.
US Geological Survey

POSTED

4 days ago

DEADLINE

in 29 days
View Details
NAICS: 541714
New
Grant
Cooperative Agreement for affiliated Partner with Gulf Coast Cooperative Ecosystem Studies Unit
Solicitation # G27AS00064
The U.S. Geological Survey Eastern Ecological Science Center is soliciting applications for a Cooperative Agreement under the Gulf Coast Cooperative Ecosystem Studies Unit to perform bioinformatic analysis on avian microbiome metatranscriptomic datasets. The research focuses on genome assembly-based identification of viruses, prokaryotic, and eukaryotic microorganisms, with a specific emphasis on zoonotic and wildlife pathogens. Awardees will analyze shotgun metatranscriptomic data to estimate microbial diversity and abundance across various host species, tissues, and geographic regions, while developing reproducible bioinformatic workflows. Key requirements include collaborating on peer-reviewed publications and making data products publicly available through repositories like ScienceBase or the National Center for Biotechnology Information. The solicitation, numbered G27AS00064, has a total program funding ceiling of 459,000 dollars for one expected award. The anticipated period of performance runs from April 1, 2027, to March 31, 2030, with applications due via grants.gov by December 7, 2026. Proposals are evaluated based on purpose and relevance, technical approach, qualifications and past performance, and budget clarity. Applicants must be registered in SAM.gov and provide specific documentation, including a Project Abstract Summary, Biographical Sketches, and Current and Pending Support forms for key personnel. All geospatial data produced must adhere to Federal Geospatial Data Committee standards and the Geospatial Data Act of 2018.
US Geological Survey

POSTED

4 days ago

DEADLINE

in about 2 months
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NAICS: 541714
New
Federal
Immunohistochemical (IHC) Analysis SupportThe Immunohistochemical (IHC) Analysis Support subcontract, issued by the NASA Shared Services Center, involves providing specialized staining and chemical analysis of sectioned tissue for prime contractors on NASA Space Biosciences projects. The scope of work requires the application of antibodies and reagents to cryo-sectioned slides and the use of fluorescence microscopes and IHC staining stations to evaluate neuronal morphology. Due to the technical nature of the work, specialized training in neuro-histology is required to deliver the final analyzed slides and digital imaging reports. This opportunity is categorized under NAICS code 541714 and is associated with a performance location in zip code 94035. The solicitation was posted on November 4, 2026, with a response deadline of November 9, 2026.
NASA Shared Services Center

POSTED

5 days ago

DEADLINE

in about 4 hours
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NAICS: 541714
New
Federal
Service request for specimen embedding and sectioning.
Solicitation # 80NSSC27948767Q
The NASA Shared Services Center is seeking custom histology research services to support a Space Biosciences Project evaluating neuronal morphology in mouse brains exposed to radiation, isolation, and simulated microgravity. The scope of work involves planning, preliminary testing, embedding, and cryo-sectioning of specific brain regions, including the substantia nigra, hippocampus, and prefrontal cortex. The contractor must provide slides with sections 15 microns thick, which are to be delivered to Principal Investigator Dr. Joshua Alwood within 90 days after receipt of order. Performance will be located at the NASA Ames Research Center. This procurement is being conducted under FAR Part 12 for commercial items and services, with the government intending to issue a sole source contract to ZYAGEN, identified as the sole provider of the required services. While the agency is currently requesting capability statements from interested organizations by November 9, 2026, to determine if a competitive procurement is feasible, it explicitly states that quotes will not be reviewed or accepted at this stage. Primary coordination for this effort is managed by Cara Craft and Will Garrett.
NASA Shared Services Center

POSTED

5 days ago

DEADLINE

in about 4 hours
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NAICS: 541714
New
SBIR / STTR
Specialized Bio-Research / Protocol Compliance ConsultantThis subcontract opportunity is for a Specialized Bio-Research / Protocol Compliance Consultant to support research and development projects for the United States Navy and Marine Corps Systems Command. The selected provider will conduct research involving recombinant DNA and human or animal subjects, ensuring all activities are executed according to strict research protocols. Key responsibilities include managing recombinant DNA activities within laboratory facilities and maintaining full compliance with federal, state, and local environmental laws regarding the handling of toxic materials. All work must be performed under the necessary IRB and IACUC approvals, with the final deliverables consisting of experimental data and feasibility reports. The contract is designated as a Total Small Business Set-Aside under NAICS code 541714, specifically targeting firms with fewer than 500 employees in alignment with SBIR/STTR mandates. Interested parties must submit their responses by December 2, 2026. This role is critical for prime contractors requiring specialized expertise in bio-research compliance and the technical execution of complex laboratory protocols within the Department of Defense framework.
United States Navy

POSTED

5 days ago

DEADLINE

in 23 days
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NAICS: 541714
New
SBIR / STTR
Biolab Mirror: Artificial Intelligence / Machine Learning (AI/ML) Digital Twin for Intent Characterization and Bio-Containment Integrity
Solicitation # DTR27TZ02-NV001
The Defense Threat Reduction Agency, under the Department of War, is soliciting proposals for the Biolab Mirror, an AI/ML-driven Digital Twin designed to ensure bio-containment integrity and characterize intent in state-sponsored biological research facilities. The project implements a Physics-to-Mesh Zero Trust architecture that cross-validates digital telemetry from LIMS, SCADA, and BMS logs against unalterable physical and biological laws, such as thermodynamics and metabolic rates. This system aims to detect clandestine pathogen scaling and containment spoofing by identifying coherence failures. Beyond its defensive application, the Biolab Mirror will serve as a cyber-physical sandbox for simulating multi-domain attacks against high-containment infrastructure, filling a critical gap in current cyber-range emulation. This is a phased STTR program with a total small business set-aside. Phase I focuses on delivering a conceptual architecture and a working software prototype, while Phase II, with a ceiling price of 1.5 million dollars, involves full project effort over a 24-month duration. Proposals are evaluated based on technical merit, investigator qualifications, and commercial potential. Applicants must be registered in SAM and the SBA Company Registry. Compliance requirements include CMMC standards for safeguarding controlled unclassified information and strict adherence to organizational conflict of interest disclosures. Proposals must be submitted via the DSIP portal by January 6, 2026.
Defense Threat Reduction Agency

POSTED

5 days ago

DEADLINE

in about 2 months
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NAICS: 541714
New
Grant
Systems Biology of Infection and Inflammation in Chronic Diseases (U19 Clinical Trial Not Allowed)
Solicitation # RFA-AI-28-014
The National Institutes of Health (NIH) issued solicitation RFA-AI-28-014 to establish centers focused on the systems-level understanding of the links between infectious pathogens, inflammatory pathways, and chronic diseases. The program supports two types of centers: Chronic and Infectious Diseases Systems Biology Centers (CIDSB), which examine the bidirectional link between chronic and infectious diseases, and Systems Biology Inflammation Centers (SBI), which focus on the role of inflammation in chronic diseases to identify precision medicine targets. The primary goals are to develop predictive computational models for disease progression, discover novel drug targets and biomarkers, and create harmonized, FAIR-compliant cross-disease datasets. The total program funding is 26 million dollars, with an expected 10 awards and an individual award ceiling of 2.5 million dollars. Applications must be submitted electronically via Grants.gov by February 18, 2027. The proposal structure is multi-component, requiring an overall section, an administrative core, a data and modeling core, and a biospecimen collection and processing core, with additional requirements for research projects and optional cores depending on the center type. Evaluation is based on an overall impact score focusing on significance and the qualifications of the investigators. Awardees must comply with strict cybersecurity incident reporting requirements, notifying the HHS awarding agency within 48 hours of discovery, and must adhere to rigorous biosafety and human subjects protection standards. Applicants must maintain active SAM registration and UEI identifiers to be eligible for funding.
National Institutes Of Health

POSTED

5 days ago

DEADLINE

in 3 months
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NAICS: 541714
New
Grant
Systems Biology of Infection and Inflammation in Chronic Diseases (U19 Clinical Trial Not Allowed)
Solicitation # RFA-AI-28-014
The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, is seeking proposals under solicitation RFA-AI-28-014 for the Systems Biology of Infection and Inflammation in Chronic Diseases. This initiative aims to advance the systems-level understanding of how infectious pathogens and inflammatory pathways contribute to the predisposition, onset, and progression of chronic diseases. The program emphasizes the integration of clinical and patient data, large-scale omics datasets, and advanced artificial intelligence and computational modeling to develop strategies for preventing, treating, and mitigating the combined effects of these conditions. This federal solicitation was posted on November 4, 2026, with a response deadline of February 19, 2027. It is important to note that clinical trials are not allowed under this specific funding opportunity. Interested parties can find further details through the provided grants portal.
National Institute Of Allergy And Infectious Diseases

POSTED

6 days ago

DEADLINE

in 3 months
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