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NAICS Code· 541714

NAICS 541714: Research and Development in Biotechnology (except Nanobiotechnology)

This U.S. industry comprises establishments primarily engaged in conducting biotechnology (except nanobiotechnology) research and experimental development. Biotechnology (except nanobiotechnology) research and experimental development involves the study of the use of microorganisms and cellular and biomolecular processes to develop or alter living or non-living materials. This research and development in biotechnology (except nanobiotechnology) may result in development of new biotechnology (except nanobiotechnology) processes or in prototypes of new or genetically-altered products that may be reproduced, utilized, or implemented by various industries. Illustrative Examples: Cloning research and experimental development laboratories DNA technologies (e.g., microarrays) research and experimental development laboratories Nucleic acid chemistry research and experimental development laboratories Protein engineering research and experimental development laboratories Recombinant DNA research and experimental development laboratories Cross-References. Establishments primarily engaged in--Show more

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms. This sector supports federal initiatives in precision medicine, infectious disease mitigation, biosecurity, and advanced bioprocessing, often involving recombinant DNA technology, protein engineering, cell line development, and high-throughput screening.

128
Active Contracts
$1.0B
Total Obligations (12mo)
446
Awarded Contracts (12mo)
300
Contractors Awarded (12mo)
1
Median Bidders per Award
-14.5%
YoY Growth

Industry Spending Overview

Federal obligations, top contractors and agencies, and related industry codes for NAICS 541714.

AI Industry Description

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms...

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms. This sector supports federal initiatives in precision medicine, infectious disease mitigation, biosecurity, and advanced bioprocessing, often involving recombinant DNA technology, protein engineering, cell line development, and high-throughput screening. In the government contracting landscape, this NAICS code serves as a critical conduit for translating academic and private-sector biotech innovations into mission-critical public health and defense capabilities, frequently intersecting with biomedical engineering, regulatory science, and clinical trial design. Top contractors in this space include Deloitte Consulting LLP, CFD Research Corporation, and PM Consulting Group LLC, reflecting a mix of large professional services firms and specialized small businesses with deep expertise in biostatistics, bioinformatics, and translational research. These firms often serve as technical integrators, bridging laboratory discoveries with scalable, compliant, and government-ready solutions, particularly in areas requiring FDA-aligned development pathways or defense-relevant biosurveillance capabilities. The Department of Health and Human Services and the Department of Defense are the primary awarding agencies, with HHS funding biomedical innovation through NIH and BARDA programs, while DoD supports biodefense, battlefield medical readiness, and countering biological threats through agencies like DARPA and the U.S. Army Medical Research and Development Command. Demand is driven by pandemic preparedness, medical countermeasure development, and next-generation biothreat detection systems. The competitive landscape is highly technical and innovation-driven, with opportunities concentrated in contract research organizations, specialized R&D services, and government-sponsored translational partnerships. Contractors with proven experience in GMP compliance, biosafety level containment, and federal regulatory submission processes are best positioned to compete in this high-stakes, mission-critical sector.

Top Contractors

Companies with the highest total award value under NAICS 541714, ranked by dollars won.

Ranked by total awards
CompanyTotal AwardsContracts
ALBERT B. SABIN VACCINE INSTITUTE, INC. (THE)$263.6M1
SHIONOGI INC.$156.1M1
CHENEGA SERVICES & FEDERAL SOLUTIONS, LLC$72.4M1
CIDARA THERAPEUTICS INC$58.1M1
VERICEL CORPORATION$34.9M1
BATTELLE MEMORIAL INSTITUTE$32.1M9
UNIVERSITY OF MIAMI$28.3M2
UES INC Dayton OH 45432 USA$25.0M1
CHENEGA PROFESSIONAL & TECHNICAL SERVICES LLC$20.6M2
PRENOSIS, INC$20.0M1

Top Agencies

Federal agencies directing the most contract spending toward NAICS 541714.

Department Of Health And Human Services163 awards$716.3M
Defense Health Agency1 award$72.4M
Department Of Defense45 awards$66.1M
Department Of Health And Human Services (hhs)107 awards$53.6M
National Institutes Of Health Nida1 award$26.6M
Department Of Veterans Affairs51 awards$25.8M
FA8650 USAF Afmc Afrl Pzl Afrl/pzl1 award$25.0M
FDA Office Of Acquisitions And Grants Services1 award$16.7M
Army Medical Resources Acq Activity1 award$11.5M
National Aeronautics And Space Administration13 awards$10.8M

Competition

How many companies historically bid on federal awards in NAICS 541714, from bidder counts reported on USAspending.

Usually Single-Bid

Half or more of reported awards drew exactly one bidder, usually a sign of incumbent-held work rather than an open field. · 4,542 reported awards

Median Bidders

1

Per reported award, all-time

Single-Bid Awards

65%

Share of reported awards with one bidder

10+ Bidder Awards

14%

Share of reported awards with 10+ bidders

Reported Awards

0

87% of 5,225 total awards

How this code compares up the NAICS hierarchy. Parent cohorts pool every code under their prefix, so they are the steadier baseline when a 6-digit sample is thin.

Industry FamilyCompetitionMedian BiddersSingle-BidBidder MixReported Awards
541714This Code
Research and Development in Biotechnology (except Nanobiotechnology)
Usually Single-Bid165%
4,54287% of 5,225
54171NAICS Industry
Fewer Bidders242%
246,33582% of 298,788
5417Industry Group
Scientific Research and Development Services
Fewer Bidders240%
282,62484% of 338,309
541Subsector
Fewer Bidders249%
2,918,78285% of 3,416,794
54Sector
Professional, Scientific, and Technical Services
Fewer Bidders249%
2,918,78285% of 3,416,794

Bidder counts reported on past federal awards in this NAICS (USAspending). An open opportunity has no bidders yet, so this is the historical norm for similar work, not a fact about this solicitation. Not all awards report bidder counts, and fewer bidders often means incumbent-held work rather than an easier win. Federal reporting of bidder counts fell from ~96% of awards (FY2016) to ~30% (FY2018 onward); the chart shows shares of reported awards, and washed-out stretches mark years with fewer than 30 of them.

Related NAICS Codes

Industries similar to Research and Development in Biotechnology (except Nanobiotechnology), by shared sector, subsector, and industry group.

Research and Development in Nanotechnology

This U.S. industry comprises establishments primarily engaged in conducting nanotechnology research ...
541713Same Industry GroupHigh Similarity

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

This U.S. industry comprises establishments primarily engaged in conducting research and experimenta...
541715Same Industry GroupHigh Similarity

Research and Development in the Social Sciences and Humanities

This industry comprises establishments primarily engaged in conducting research and analyses in cogn...
541720Same Industry GroupHigh Similarity

Offices of Lawyers

This industry comprises offices of legal practitioners known as lawyers or attorneys (i.e., counselo...
541110Same SubsectorMedium Similarity

Offices of Notaries

This industry comprises establishments (except offices of lawyers and attorneys) primarily engaged i...
541120Same SubsectorMedium Similarity

title Abstract and Settlement Offices

This U.S. industry comprises establishments (except offices of lawyers and attorneys) primarily enga...
541191Same SubsectorMedium Similarity

All Other Legal Services

This U.S. industry comprises establishments of legal practitioners (except offices of lawyers and at...
541199Same SubsectorMedium Similarity

Offices of Certified Public Accountants

This U.S. industry comprises establishments of accountants that are certified to audit the accountin...
541211Same SubsectorMedium Similarity

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NAICS 541714 FAQ

Frequently Asked Questions

NAICS code 541714 covers Research and Development in Biotechnology (except Nanobiotechnology). This U.S. industry comprises establishments primarily engaged in conducting biotechnology (except nanobiotechnology) research and experimental development. Biotechnology (except nanobiotechnology) research and experimental development involves the study of the use of microorganisms and cellular and biomolecular processes to develop or alter living or non-living materials. This research and development in biotechnology (except nanobiotechnology) may result in development of new biotechnology (except nanobiotechnology) processes or in prototypes of new or genetically-altered products that may be reproduced, utilized, or implemented by various industries. Illustrative Examples: Cloning research and experimental development laboratories DNA technologies (e.g., microarrays) research and experimental development laboratories Nucleic acid chemistry research and experimental development laboratories Protein engineering research and experimental development laboratories Recombinant DNA research and experimental development laboratories Cross-References. Establishments primarily engaged in--

Recently Posted in Research and Development in Biotechnology (except Nanobiotechnology)

NAICS: 541714
New
Federal
TIDAL: Target-Induced Droplet Assembly of Ligands
Solicitation # S-197478
Developed by Los Alamos National Laboratory, TIDAL (Target-Induced Droplet Assembly of Ligands) is a programmable protein-only material that utilizes nanobodies fused with encapsulation peptides to create dynamic, liquid-like droplets through phase separation. This technology allows for the precise concentration of binders upon encountering a target ligand, enabling a versatile platform for resin-free protein purification, high-sensitivity diagnostics, and the creation of slow-release drug depots. It can also function intracellularly to sequester and neutralize harmful proteins associated with viral infections or cancer. The technology is currently at TRL 3 with a patent pending and is available for exclusive or non-exclusive licensing through the Department of Energy contractor, Triad. Key market applications span biopharmaceutical manufacturing, therapeutics, and biotechnology. Interested parties can contact Caleb Ledgerwood or Lindsay Augustyn via the provided licensing email to explore commercial partnerships for this innovation.
Triad - DOE Contractor

POSTED

2 days ago

DEADLINE

in 3 months
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NAICS: 541714
New
Federal
Future Program: Firefox
Solicitation # DARPA-SN-26-113
The Defense Advanced Research Projects Agency's Biological Technologies Office has issued Special Notice DARPA-SN-26-113 to announce research areas of interest for the upcoming Firefox program. This notice serves as a public notification for potential applicants regarding the agency's objectives and the contemplated forthcoming solicitation. The notice was posted on September 4, 2026, with a response deadline of September 11, 2026. Managed by the Department of Defense in Arlington, Virginia, the program falls under NAICS code 541714. Interested parties can contact Dr. Pedro Irazoqui for further information, and the official solicitation will be hosted on the SAM.gov website.
Defense Advanced Research Projects Agcy

POSTED

6 days ago

DEADLINE

in about 20 hours
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NAICS: 541714
New
Federal
Chemical, Biological, Radiological and Nuclear Advance Defense Enabling Network and Clinical Capability (CADENCC)
Solicitation # W911SR-26-9-CADENCC
The Department of the Army, through the Army Contracting Command Edgewood Contracting Division and the Joint Project Lead Enabling Technologies, is seeking preproposals for the Chemical, Biological, Radiological and Nuclear Advance Defense Enabling Network and Clinical Capability project. This initiative aims to accelerate clinical trial startups for CBRN defense readiness by implementing Master Protocols, utilizing innovative technologies for decentralized trial operations, and establishing a pre-positioned clinical trial site network. The project will primarily focus on Phase I and Phase II clinical trials for early treatment products, post-exposure prophylaxis, and pre-exposure prophylaxis, including those under the Animal Rule. This opportunity is issued under 10 USC 4022 Other Transaction Authority for a prototype project, with the potential for non-competitive follow-on production contracts for successful performers. Preproposals are due by 1500 hours on September 17, 2026, and must be limited to 10 pages. Evaluation will be based on technical merit, military relevance, technology readiness level 4 or above, regulatory compliance with FDA guidelines, and best overall value. Prospective awardees must be registered in the System for Award Management database.
W6QK Acc-Apg

POSTED

6 days ago

DEADLINE

in 7 days
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NAICS: 541714
Awarded
Federal
Low-Pass Sequencing of Cotton Accessions - College Station TX
Solicitation # 1232SA26P0673
USDA Ars Afm Apd

POSTED

6 days ago

DEADLINE

N/A
View Details
NAICS: 541714
Closed
Federal
Q301--Strand-Specific RNA-Sequencing Services
Solicitation # 36C24126Q0788
Solicitation 36C24126Q0788 is a firm-fixed-price request for quotations issued by the Department of Veterans Affairs, Network Contracting Office 1, for strand-specific RNA-sequencing services to support the VA Bedford Healthcare System. This requirement is set aside 100 percent for small business concerns under NAICS 541714. The project involves the sequencing of 269 government-furnished human choroid plexus total RNA samples to support research on neurodegenerative diseases, including Alzheimer’s Disease and Chronic Traumatic Encephalopathy. The selected contractor must provide sample quality-control assessment, rRNA depletion-based library preparation, and Illumina paired-end 2x150bp sequencing at a depth of approximately 60 million read pairs per sample. The period of performance is one year from the date of award, with a strict turnaround requirement to complete all services and deliver FASTQ files and quality-control reports within 23 to 28 business days after receiving the samples as a single batch. Technical acceptance requires that at least 85 percent of bases achieve a Phred quality score of Q30 or greater. Data delivery is primarily via physical hard drive, though secure electronic delivery may be authorized. Award will be made to the responsible quoter submitting the lowest-priced technically acceptable quotation, based on an evaluation of the technical capability statement and total price. Quotations are due by September 10, 2026, at 11:00 AM Eastern Time.
241-NETWORK Contract Office 01 (36C241)

POSTED

7 days ago

CLOSED

32 minutes ago
View Details
NAICS: 541714
Federal
Rapid Prototyping and Hardware EngineerThis subcontract with the Defense Advanced Research Projects Agency focuses on the design, development, and manufacturing of next-generation military hardware for prime contractors. The scope of work involves executing rapid prototyping and scalable deployment strategies through the use of additive manufacturing and high-fidelity testing environments. Key deliverables include hardware prototypes, technical design documents, and comprehensive manufacturing scalability plans. The project requires strict adherence to NIST SP 800-171 and DoDI 8582.01 standards to ensure the protection of Controlled Unclassified Information. Classified under NAICS code 541714, the opportunity was posted on September 3, 2026, with a response deadline of June 1, 2027.
Defense Advanced Research Projects Agcy

POSTED

7 days ago

DEADLINE

in 9 months
View Details
NAICS: 541714
Closed
Federal
USDA ARS - Wheat Whole Genome Sequencing
Solicitation # 1232SA26Q1410
Solicitation number 1232SA26Q1410 is a request for quotations for Wheat Whole Genome Sequencing on behalf of the USDA ARS. This combined synopsis and solicitation is issued as a total set-aside for small business concerns under NAICS code 541714, with a size standard of 1,000 employees. The opportunity was posted on September 3, 2026, with a response deadline of September 9, 2026. While the contracting office is located in San Bernardino, California, the place of performance is in Raleigh, North Carolina. Interested parties should direct inquiries to the primary point of contact, Grace Walton.
San Bernardino National Forest

POSTED

7 days ago

CLOSED

about 23 hours ago
View Details
NAICS: 541714
Federal
HUBBLE Proposers Day
Solicitation # DARPA-SN-26-121
The Defense Advanced Research Projects Agency's Biological Technologies Office is hosting a Proposers Day for the High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators program. This event is scheduled for September 25, 2026, from 12:00 PM to 5:00 PM Eastern Time at the SPA Arlington Research Collaboration Center in Arlington, Virginia. While a hybrid option is available for attendees, all presenters are required to be present in person. Interested parties must complete advance registration by the response deadline of September 18, 2026. This special notice, identified by solicitation number DARPA-SN-26-121 and NAICS code 541714, serves as a preparatory step for a planned Program Announcement. Primary coordination for the event is managed by Dr. Abhishek Singharoy.
Defense Advanced Research Projects Agcy

POSTED

7 days ago

DEADLINE

in 8 days
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NAICS: 541714
Federal
Myocardial Intramural Remodeling by Transvenous tether (MIRTH) Implant Design Support and Feasibility Prototypes
Solicitation # 75N98026Q01129
The National Institutes of Health Nhlbi, under the Department of Health and Human Services, is seeking a contractor for the Myocardial Intramural Remodeling by Transvenous tether (MIRTH) Implant Design Support and Feasibility Prototypes project. This presolicitation, identified by solicitation number 75N98026Q01129, falls under NAICS code 541714 and focuses on the design and prototyping of medical implants. The project will be performed in Bethesda, Maryland. Interested parties must submit their responses by the deadline of September 10, 2026, at 4:00 PM. Primary inquiries and coordination for this effort are managed by Noelle Decenzo.
National Institutes Of Health Nhlbi

POSTED

7 days ago

DEADLINE

in 28 minutes
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NAICS: 541714
Federal
Hypobaric Chamber Pilot Studies
Solicitation # 80JSC026Q0006
NASA Johnson Space Center is soliciting quotes under RFQ 80JSC026Q0006 for pilot hypobaric chamber testing facilities to support decompression sickness research for the Artemis program. The primary objective is to validate non-NASA resources for safe prebreathe procedures and extravehicular activity. The contractor must provide all personnel, equipment, and facilities to conduct three test days, recruiting at least two subjects per day to demonstrate the ability to meet NASA testing throughput and schedules. The base period of performance is from September 1, 2026, to September 30, 2027, with several optional work items available through September 30, 2029, including additional test days, pharmaceutical-enhanced prebreathe, and body temperature studies. This is a small business set-aside acquisition under NAICS 541714. Awards will be made based on a trade-off analysis where technical acceptability and past performance are significantly more important than price. Technical evaluation focuses on facility capabilities, medical support, team expertise, and the proposed schedule. Offerors must submit their quotes by September 10, 2026, at 1:00 p.m. Central Time. Submissions must include a completed pricing sheet and documentation of qualifications as specified in the additional submission criteria. The contract is governed by FAR Part 12 for commercial products and services and includes a total duration not to exceed five years.
NASA Johnson Space Center

POSTED

7 days ago

DEADLINE

in about 3 hours
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NAICS: 541714
Closed
Federal
Sole Source Chapter PomePlex-26 NGS Assay (96 tests)
Solicitation # 1173878
The Department of Agriculture, through the Animal and Plant Health Inspection Service, is issuing a sole source notification for the acquisition of 10 ChapterDx PomePlex 26 kits. This technology is required for the Plant Germplasm Quarantine Program to streamline the screening of 26 viruses and viroids in pome trees, replacing a laborious individual PCR process with a single tube reaction. Each kit provides reagents for 96 individual samples, supporting a project funded by the Plant Protection Act PPA7721 Spending plan for FY26. ChapterDx is identified as the only provider offering a 26 NGS assay compatible with existing laboratory workflows that allows for sequencing in a 96 sample format using minimal sample volumes. This procurement is designated as a Total Small Business Set Aside under NAICS code 541714. The notice is managed by Todd Bierl and closes on September 7, 2026, at 12:00 PM CST.
Ppq Beltsville Md

POSTED

8 days ago

CLOSED

3 days ago
View Details
NAICS: 541714
Federal
Illumina DRAGEN GCP Lvl 4 1-year License
Solicitation # 75N98026Q01035
The National Institutes of Health, through the National Institute of Neurological Disorders and Stroke, is seeking a 12-month subscription to the Illumina DRAGEN GCP Level 4 platform under solicitation 75N98026Q01035. This contract is intended to support neurodegenerative disease research by processing approximately 1,300,000 GB of whole-genome sequencing data from 10,000 human genomes. The platform must provide graph-based alignment to the hg38 human reference genome and ensure accurate detection of single-nucleotide variants, insertions, deletions, structural variants, copy number variants, and repeat expansions. The selected contractor must ensure full compatibility with Illumina-generated sequencing data and existing DRAGEN-processed datasets, delivering outputs in CRAM and VCF file formats. This procurement is contemplated as a sole-source action to Illumina, Inc., with a total estimated cost of 113,004 dollars. The period of performance is 12 months, and the requirement is managed by the Department of Health and Human Services in Bethesda, Maryland.
National Institutes Of Health Olao

POSTED

8 days ago

DEADLINE

in 28 minutes
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